Down-Regulation Influences Cardiac Hypertrophic Response and Progression Toward Heart Failure: Protective Role of S1PR1 Cardiac Gene Therapy
نویسندگان
چکیده
Alessandro Cannavo, PhD*; Giuseppe Rengo, MD, PhD*; Daniela Liccardo, PhD*; Gennaro Pagano, MD; Carmela Zincarelli, MD, PhD; Maria Carmen De Angelis, MD; Roberto Puglia, MD; Elisa Di Pietro, MD, PhD; Joseph E. Rabinowitz, PhD; Maria Vittoria Barone, MD, PhD; Plinio Cirillo, MD, PhD; Bruno Trimarco, MD, PhD; Timothy M. Palmer, PhD; Nicola Ferrara, MD; Walter J. Koch, PhD; Dario Leosco, MD, PhD; Antonio Rapacciuolo, MD, PhD
منابع مشابه
β1-adrenergic receptor and sphingosine-1-phosphate receptor 1 (S1PR1) reciprocal downregulation influences cardiac hypertrophic response and progression to heart failure: protective role of S1PR1 cardiac gene therapy.
BACKGROUND The sphingosine-1-phosphate receptor 1 (S1PR1) and β1-adrenergic receptor (β1AR) are G-protein-coupled receptors expressed in the heart. These 2 receptors have opposing actions on adenylyl cyclase because of differential G-protein coupling. Importantly, both of these receptors can be regulated by the actions of G-protein-coupled receptor kinase-2, which triggers desensitization and d...
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تاریخ انتشار 2013